Microbiota-Dependent Sequelae of Acute Infection Compromise Tissue-Specific Immunity
نویسندگان
چکیده
منابع مشابه
Microbiota-Dependent Sequelae of Acute Infection Compromise Tissue-Specific Immunity
Infections have been proposed as initiating factors for inflammatory disorders; however, identifying associations between defined infectious agents and the initiation of chronic disease has remained elusive. Here, we report that a single acute infection can have dramatic and long-term consequences for tissue-specific immunity. Following clearance of Yersinia pseudotuberculosis, sustained inflam...
متن کاملImmunity, gut microbiota and infection
Recurrent infections are very common in children and a major challenge for pediatricians. They affect the children’s quality of life, cause absences from school and lost parental working days, and repeated medical examinations, hospital admissions as well as antibiotic therapies lead to high costs for society. Given their prevalence and clinical importance, various prevention strategies have be...
متن کاملCCR7-dependent immunity during acute Toxoplasma gondii infection.
The chemokine receptor CCR7 is a well-established homing receptor for dendritic cells and T cells. Interactions with its ligands, CCL19 and CCL21, facilitate priming of immune responses in lymphoid tissue, yet CCR7-independent immune responses can be generated in the presence of sufficient antigen. In these studies, we investigated the role of CCR7 signaling in the generation of protective immu...
متن کاملSpecific Tuberculosis Immunity During Infection *
The variegated picture of tuiberculous infection, both spontaneous in man and experimentally induced in animals, has puzzled students and led to most complicated explanations. Most of the earlier experimental studies were handicapped by the lack of two fundamentals which now appear so essential to a solution. One of these was the primary lack of information on the tubercle bacillus and its viru...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell
سال: 2015
ISSN: 0092-8674
DOI: 10.1016/j.cell.2015.08.030